4-Methylmorpholine → HCID 22870501, compound

HRID 975810Notes

Reaction equation

HRID 975810 reaction equation
Cl.[NH2:2][C@H:3]1[C:9](=[O:10])[N:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[O:5][CH2:4]1.[CH2:25]([O:27][C:28](=[O:51])[C@H:29](OS(C1C=CC([N+]([O-])=O)=CC=1)(=O)=O)[CH2:30][CH2:31][CH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1)[CH3:26].CN1CCOCC1>CCCCCC.C(OCC)(=O)C>[CH2:25]([O:27][C:28]([C@@H:29]([NH:2][C@H:3]1[C:9](=[O:10])[N:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]=2[O:5][CH2:4]1)[CH2:30][CH2:31][CH:32]1[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1)=[O:51])[CH3:26]

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 54177175HCID 54177175, compoundHCID 67713878HCID 67713878, compound

Product 1

HCID 22870501HCID 22870501, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Obtained analogously to the directions in Example 1c) starting from (R)-3-amino-5-(p-isopropylbenzyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine hydrochloride, 2.93 g of (R)-alpha-[[(4-nitrophenyl)sulfonyl]oxy]-4-cyclohexylbutyric acid ethyl ester and 1.85 ml of N-methylmorpholine. Colourless resin, Rf value (eluant hexane/ethyl acetate 4:1): 0.36.

Workup

  1. customObtained analogously to the directions in Example 1c)

Sources & evidence

ORD record
ord-2cf254565b114fbe9f35e6942aa60e6f
Source dataset
uspto-grants-1997_03
Patent number
US05610153

Reaction notes

Loading…