反应详情

温度

130 °C

A mixture of ethyl 1-aminocyclohexanecarboxylate (669 g), potassium carbonate (683.1 g) and ethyl 4-bromobutyrate (558 ml) was stirred at 130° C. for 18 hours, then cooled to ambient temperature and poured onto ice-water (3 l). The product was extracted into dichloromethane and the combined extracts were dried over sodium sulphate and the solvent was removed in vacuo to yield ethyl 1-(3-ethoxycarbonylpropylamino)cyclohexanecarboxylate as a brown/orange oil. Yield 943.2 g.

1. temperaturecooled to ambient temperature
2. additionpoured onto ice-water (3 l)
3. extractionThe product was extracted into dichloromethane
4. dry with materialthe combined extracts were dried over sodium sulphate
5. customthe solvent was removed in vacuo