関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl 4-bromobutyrate | HCID 76300 | — |
| 反応物 | Ethyl 1-aminocyclohexanecarboxylate | HCID 222863 | — |
| 生成物 | Ethyl 1-(3-ethoxycarbonylpropylamino)cyclohexanecarboxylate | HCID 13282875 | — |
反応手順
A mixture of ethyl 1-aminocyclohexanecarboxylate (669 g), potassium carbonate (683.1 g) and ethyl 4-bromobutyrate (558 ml) was stirred at 130° C. for 18 hours, then cooled to ambient temperature and poured onto ice-water (3 l). The product was extracted into dichloromethane and the combined extracts were dried over sodium sulphate and the solvent was removed in vacuo to yield ethyl 1-(3-ethoxycarbonylpropylamino)cyclohexanecarboxylate as a brown/orange oil. Yield 943.2 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05610161 |
|---|
| 出典データセット | uspto-grants-1997_03 |
|---|
| ORD ID | ord-40fb88ba0f324bcc8f0a527c3d225990 |
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| 出典メモ | uspto-grants-1997_03 |
|---|
