反应详情

3.44 g (13 mmol) Triphenylphosphine was dissolved in 100 ml dry toluene, in a 250 ml flask with an argon feed. 3 g (13 mmol) 4-(bromomethyl)benzoic acid methyl ester was added, and the mixture was heated 2 hr at reflux, with stirring. The white phosphonium salt which precipitated was separated out from the cooled mixture, washed with absolute toluene, and dried in a vacuum. The fine crystals melted at 251°-252° C. Yield: 5.85 g (91%).

1. temperaturethe mixture was heated 2 hr
2. temperatureat reflux
3. customThe white phosphonium salt which precipitated
4. customwas separated out from the cooled mixture
5. washwashed with absolute toluene
6. customdried in a vacuum