m-Tolyl isocyanate → HCID 67713309, compound

HRID 975954Notes

Reaction equation

HRID 975954 reaction equation
[NH2:1][CH2:2][C:3]([N:5]1[C@H:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][C@@H:6]1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:4].[CH3:22][C:23]1[CH:24]=[C:25]([N:29]=[C:30]=[O:31])[CH:26]=[CH:27][CH:28]=1>O1CCCC1>[C:16]1([CH:6]2[CH2:7][CH2:8][CH:9]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:5]2[C:3](=[O:4])[CH2:2][NH:1][C:30]([NH:29][C:25]2[CH:26]=[CH:27][CH:28]=[C:23]([CH3:22])[CH:24]=2)=[O:31])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 53822447HCID 53822447, compound

Product 1

HCID 67713309HCID 67713309, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By proceeding in a fashion similar to that described in Example 2, but starting from 2 g of cis-1-(2-aminoacetyl)-2,5-diphenylpyrrolidine and 0.9 cm3 of 3-methylphenyl isocyanate in solution in 25 cm3 of anhydrous tetrahydrofuran, 1.4 g of (2RS,5SR)-1-[2-(2,5-diphenyl-1-pyrrolidinyl)-2-oxoethyl]-3-(3-methylphenyl)urea, melting at 168° C., are obtained after recrystallization in 2-propanol.

Sources & evidence

ORD record
ord-5e63641c4b9e4981834b861fdc376a90
Source dataset
uspto-grants-1997_03
Patent number
US05610144

Reaction notes

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