(S,S)-2,7-Bis(tert-butyloxycarbonylamino)-4-benzyloxycarbonyl-4-azaoctanedioic acid → HCID 57132969, compound

HRID 976025Notes

Reaction equation

HRID 976025 reaction equation
C(OC([NH:8][C@@H:9]([CH2:13][N:14]([C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:15][CH2:16][C@H:17]([NH:21]C(OC(C)(C)C)=O)[C:18]([OH:20])=[O:19])[C:10]([OH:12])=[O:11])=O)(C)(C)C>C(O)(C(F)(F)F)=O>[NH2:8][C@@H:9]([CH2:13][N:14]([C:29]([O:31][CH2:32][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)=[O:30])[CH2:15][CH2:16][C@H:17]([NH2:21])[C:18]([OH:20])=[O:19])[C:10]([OH:12])=[O:11]

Participants

3

Reactant 1

HCID 57047504(S,S)-2,7-Bis(tert-butyloxycarbonylamino)-4-benzyloxycarbonyl-4-azaoctanedioic acid

Product 1

HCID 57132969HCID 57132969, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

(S,S)-2,7-Bis(tert-butyloxycarbonylamino)-4-benzyloxycarbonyl-4-azaoctanedioic acid (0.29 g, 0.37 mmol) was dissolved in TFA (10 ml), the solution stirred at ambient temperature for 2 hours and the TFA distilled off to yield the title compound which was used in the subsequent step without further purification.

Workup

  1. distillationthe TFA distilled off

Sources & evidence

ORD record
ord-52dfc49a79f24beebb1e41d305e7ee84
Source dataset
uspto-grants-1997_03
Patent number
US05610141

Reaction notes

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