Water → HCID 131719915, compound

Participants

Reaction Steps

A solution of 0.108 g (0.18 mmole) of trans methyl 1-(N-(3-chlorophenyl)-N-(phenyl)-aminocarbonyl)-2-(RS)-(2-(N-(2-methoxybenzyl) -N-methylamino)ethylaminocarbonyl)piperidine-4-(RS)carboxylate in 2.2 mL of dry THF was treated with 1.5 mL of water and then 0.073 mL of a 2.5N aqueous solution of sodium hydroxide, and the mixture was stirred at room temperature for 15 hr. The mixture was concentrated partly in a vigorous stream of nitrogen and partly in vacuo, and was used as is in further reactions.

Provenance & Evidence