Water → HCID 131719915, compound

HRID 976105Notes

Reaction equation

HRID 976105 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:9]([N:11]2[CH2:16][CH2:15][C@@H:14]([C:17]([O:19]C)=[O:18])[CH2:13][C@@H:12]2[C:21]([NH:23][CH2:24][CH2:25][N:26]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][CH3:36])[CH3:27])=[O:22])=[O:10])[CH:5]=[CH:6][CH:7]=1.O.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:9]([N:11]2[CH2:16][CH2:15][C@@H:14]([C:17]([OH:19])=[O:18])[CH2:13][C@@H:12]2[C:21]([NH:23][CH2:24][CH2:25][N:26]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][CH3:36])[CH3:27])=[O:22])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 131719916HCID 131719916, compound

Product 1

HCID 131719915HCID 131719915, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.108 g (0.18 mmole) of trans methyl 1-(N-(3-chlorophenyl)-N-(phenyl)-aminocarbonyl)-2-(RS)-(2-(N-(2-methoxybenzyl) -N-methylamino)ethylaminocarbonyl)piperidine-4-(RS)carboxylate in 2.2 mL of dry THF was treated with 1.5 mL of water and then 0.073 mL of a 2.5N aqueous solution of sodium hydroxide, and the mixture was stirred at room temperature for 15 hr. The mixture was concentrated partly in a vigorous stream of nitrogen and partly in vacuo, and was used as is in further reactions.

Workup

  1. concentrationThe mixture was concentrated partly in a vigorous stream of nitrogen and partly in vacuo

Sources & evidence

ORD record
ord-9588ea960d4441b79f46027b81569976
Source dataset
uspto-grants-1997_03
Patent number
US05610165

Reaction notes

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