Dibenzylamine → HCID 131719917, compound

HRID 976106Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:9]([N:11]2[CH2:16][CH2:15][C@@H:14]([C:17](O)=[O:18])[CH2:13][C@@H:12]2[C:20]([NH:22][CH2:23][CH2:24][N:25]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[O:34][CH3:35])[CH3:26])=[O:21])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH2:42]([NH:49][CH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:9]([N:11]2[CH2:16][CH2:15][C@@H:14]([C:17]([N:49]([CH2:42][C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[CH2:50][C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)=[O:18])[CH2:13][C@@H:12]2[C:20]([NH:22][CH2:23][CH2:24][N:25]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[O:34][CH3:35])[CH3:26])=[O:21])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7656Dibenzylamine

HCID 131719915HCID 131719915, compound

Product 1

HCID 131719917HCID 131719917, compoundYield 33%

Procedure

According to the procedure given in Example 2, Step E, 0.051 g of trans 1-(N-(3-chlorophenyl)-N-(phenyl)-aminocarbonyl)-2-(RS)-(2-(N-(2-methoxybenzyl)-N-methylamino)ethylaminocarbonyl)-piperidine-4-(RS)-carboxylic acid and 0.035 g of dibenzylamine gave 22 mg (33%) of an oil.

Sources & evidence

ORD record: ord-dac4348bfc2d4b20827bbfa66ec21713
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05610165

Reaction notes

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