HCID 70279824, compound → HCID 19968956, compound

HRID 976147Notes

Reaction equation

HRID 976147 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)=[O:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>[Pt]=O.CO>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)=[O:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 70279824HCID 70279824, compound

Product 1

HCID 19968956HCID 19968956, compoundYield 78.6%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

To 6.74 g of (E)-4-[3-(1-acetylpiperidin-4-yl)propenoyl]nitrobenzene were added 300 ml of methanol and 0.30 g of platinum oxide, and under a hydrogen stream, the mixture was stirred at room temperature for 3 hours. Then, the solid was removed by filtration, the solvent was removed by distillation under reduced pressure, and the obtained residue was applied to silica gel column chromatography to obtain 4.81 g of the title compound as brownish white powder.

Workup

  1. customThen, the solid was removed by filtration
  2. customthe solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-800121956b7348c6a33d5c7cc5c8a0aa
Source dataset
uspto-grants-1997_03
Patent number
US05610303

Reaction notes

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