Sodium Methoxide → 4-Methoxy-6-(trifluoromethyl)pyrimidin-2-amine

HRID 976219Notes

Reaction equation

HRID 976219 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[N:3]=1.[CH3:13][O-:14].[Na+]>C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([O:14][CH3:13])[CH:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[N:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 130869074-Chloro-6-(trifluoromethyl)pyrimidin-2-amine

Product 1

HCID 6061934-Methoxy-6-(trifluoromethyl)pyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Amino-4-ethoxy-6-trifluoromethylpyrimidine of melting point 114°-116° C. was obtained in a similar manner by reacting 2-amino-4-chloro-6-trifluoromethylpyrimidine with sodium methylate in ethanol.

Sources & evidence

ORD record
ord-9fddfb9c29874201b6361c4dfe7c53b0
Source dataset
uspto-grants-1997_03
Patent number
US05612286

Reaction notes

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