Oxalyl chloride → HCID 19966721, compound

HRID 976221Notes

Reaction equation

HRID 976221 reaction equation
C(Cl)(=O)[C:2](Cl)=[O:3].[NH2:7][C:8]1[N:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([C:16]([F:19])([F:18])[F:17])[N:9]=1>C1(C)C=CC=CC=1>[N:7]([C:8]1[N:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([C:16]([F:19])([F:17])[F:18])[N:9]=1)=[C:2]=[O:3]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 6061934-Methoxy-6-(trifluoromethyl)pyrimidin-2-amine

Product 1

HCID 19966721HCID 19966721, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

38.3 g of oxalyl chloride (0.3 mol) were added dropwise to a suspension of 2-amino-4-methoxy-6-trifluoromethylpyrimidine (78 mmol) in 100 ml of toluene. The refluxing mixture was stirred for 4 hours, after which the homogeneous solution obtained was subjected to fractional distillation. The title compound (9.9 g; 58% of theory) was obtained as an oil of boiling point 44°-50° C. (0.5 mbar).

Workup

  1. customafter which the homogeneous solution obtained
  2. distillationwas subjected to fractional distillation

Sources & evidence

ORD record
ord-c6c5d269d654431192be2132ed123267
Source dataset
uspto-grants-1997_03
Patent number
US05612286

Reaction notes

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