反应详情

To a solution of 1.5 g of methyl 6-amino-pyridine-3-carboxylate in 100 ml of methylene chloride is added 3 ml of N,N-diisopropylethylamine at room temperature. To the stirred reaction mixture is slowly added a solution of 2.5 g of [1,1'-biphenyl]-2-carbonyl chloride. The reaction mixture is stirred at room temperature for 4 hours and then quenched with water. The organic layer is washed well with water and dried over anhydrous MgSO4, filtered and evaporated in vacuo to a solid residue. The residue is stirred with ether, filtered and dried to give 3.0 g of the desired product:M+ =332.

1. customTo the stirred reaction mixture
2. customquenched with water
3. washThe organic layer is washed well with water
4. dry with materialdried over anhydrous MgSO4
5. filtrationfiltered
6. customevaporated in vacuo to a solid residue
7. stirringThe residue is stirred with ether
8. filtrationfiltered
9. customdried