Diethyl Ether → 1-(benzo[b]thiophen-5-yl)-2-(N-methylaminoethoxy)ethanol hydrochloride

In 15 ml of ethanol was dissolved 1.5 g of 1-(benzo[b]thiophen-5-yl)-1-(2-tetrahydropyranyloxy)-2-[2-(p-toluenesulfonyloxy)ethoxy]ethane. To the solution was added 4.9 ml of a 40% aqueous methylamine solution. The resulting mixture was refluxed for 1 hour. The reaction mixture was added to a mixture of 20 ml of ice water and 20 ml of diethyl ether. The organic layer was separated. The aqueous layer was extracted with 20 ml of diethyl ether. The extreact was combined with the previously separated organic layer. To the combined organic layer was added 20 ml of water. The resulting mixture was adjusted to pH 1.5 with 6N hydrochloric acid and stirred at room temperature for 20 minutes. The aqueous layer was separated. The organic layer was extracted with 10 ml of water. The extract was combined aqueous layer was added 30 ml of methylene chloride. The resulting mixture was adjusted to pH 11 with a 10% aqueous sodium hydroxide solution. The organic layer was separated. The aqueous layer was extracted with 15 ml of methylene chloride. The extract was combined with the previously separated organic layer and the combined organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure. The residue thus obtained was dissolved in 7 ml of acetone. To the solution was added 0.5 ml of a 5N dry hydrogen chloride-ethanol solution. The resulting mixture was stirred at room temperature for 1 hour. To the reaciton mixture was added 7 ml of diethyl ether. The resulting crystals were collected by filtration to obtain 0.5 g of 1-(benzo[b]thiophen-5-yl)-2-(N-methylaminoethoxy)ethanol hydrochloride (compound No. 347).

1. temperatureThe resulting mixture was refluxed for 1 hour
2. customThe organic layer was separated
3. extractionThe aqueous layer was extracted with 20 ml of diethyl ether
4. additionTo the combined organic layer was added 20 ml of water
5. customThe aqueous layer was separated
6. extractionThe organic layer was extracted with 10 ml of water
7. additionwas added 30 ml of methylene chloride
8. customThe organic layer was separated
9. extractionThe aqueous layer was extracted with 15 ml of methylene chloride
10. dry with materialthe combined organic layer was dried over anhydrous magnesium sulfate
11. customThe solvent was removed by distillation under reduced pressure
12. customThe residue thus obtained
13. stirringThe resulting mixture was stirred at room temperature for 1 hour
14. filtrationThe resulting crystals were collected by filtration

ORD record

ord-355879f4d26242a4b25be740b5a1f6dd

Source dataset

uspto-grants-1997_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05612381