3-Pyridinemethanol → (Benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol

HRID 976548Notes

Reaction equation

HRID 976548 reaction equation
O1C=CC2C=C(C3CO3)C=CC1=2.N1C=CC=C(CO)C=1.[S:21]1[CH:25]=[CH:24][C:23]2[CH:26]=[C:27]([CH:30]3[CH2:32][O:31]3)[CH:28]=[CH:29][C:22]1=2.[CH:33]([N:35]1[CH2:40][CH2:39][N:38]([CH:41]=[O:42])[CH2:37][CH:36]1[CH2:43][OH:44])=[O:34]>>[S:21]1[CH:25]=[CH:24][C:23]2[CH:26]=[C:27]([CH:30]([OH:31])[CH2:32][O:44][CH2:43][CH:36]3[CH2:37][N:38]([CH:41]=[O:42])[CH2:39][CH2:40][N:35]3[CH:33]=[O:34])[CH:28]=[CH:29][C:22]1=2

Participants

5

Reactant 4

HCID 75103-PyridinemethanolHCID 151866292-(Benzo[b]thiophen-5-yl)oxiraneHCID 450995842-(Hydroxymethyl)piperazine-1,4-dicarbaldehydeHCID 451225992-(Benzo[b]furan-5-yl)oxirane

Product 1

HCID 53826975(Benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol

Procedure

The same procedure as in Production Example 43 was repeated, except that the 2-(benzo[b]furan-5-yl)oxirane and the 3-pyridinemethanol were replaced by 2-(benzo[b]thiophen-5yl)oxirane and 1,4-diformyl-2-piperazinemethanol, respecitvely, to obtain oily 1-(benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol (compound No. 354).

Sources & evidence

ORD record
ord-a3271029c1064ec69595e4ad3ab6a8bb
Source dataset
uspto-grants-1997_03
Patent number
US05612381

Reaction notes

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