Sodium Hydroxide → HCID 18433785, compound

HRID 976618Notes

Reaction equation

HRID 976618 reaction equation
[C:1]1(=[N:9][OH:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([BH3-])#N.[Na+].[OH-].[Na+]>C(O)(=O)C>[CH:1]1([NH:9][OH:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 136841Cyclooctanone, oximeHCID 5003444Sodium cyanoborohydride

Product 1

HCID 18433785HCID 18433785, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution containing cyclooctanone oxime (9.0 g, 64 mmol) in glacial acetic acid (90 mL) was slowly charged with sodium cyanoborohydride (6.0 g, 95 mmol). The reaction mixture was stirred at ambient temperature for 18 hours then adjusted to pH=9 by the slow addition of cold 2N sodium hydroxide. The resulting precipitate was collected and dried to provide cyclooctyl hydroxylamine as a white solid.

Workup

  1. customThe resulting precipitate was collected
  2. customdried

Sources & evidence

ORD record
ord-1d6f8486b22345fea3bb44f78a39cad9
Source dataset
uspto-grants-1997_03
Patent number
US05612377

Reaction notes

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