反应详情

Ammonium formate (7.9 g, 125 mmol) and 10% palladium on carbon (2 g) were added to a solution of tert-butyl-N-benzyloxy-N-(2-methylpropyl)carbamate (Compound 54 Part B, 6.27 g, 22.4 mmol) in ethanol (100 mL). The reaction mixture was stirred at ambient temperature for 5 hours then concentrated under vacuum at 50° C. The residue was taken up in methylene chloride, washed with water, dried with magnesium sulfate and then concentrated to provide 4.2 g of tert-butyl N-hydroxy-N-(2-methylpropyl)carbamate as a yellow oil.

1. concentrationthen concentrated under vacuum at 50° C
2. washwashed with water
3. dry with materialdried with magnesium sulfate
4. concentrationconcentrated