Methylparaben → HCID 19967413, compound

HRID 976655Notes

Reaction equation

HRID 976655 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.Br[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:16]1([CH2:15][CH2:14][CH2:13][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7456MethylparabenHCID 12503(3-Bromopropyl)benzene

Product 1

HCID 19967413HCID 19967413, compoundYield 90.1%

Procedure

Using the general method of Compound 80 Part A, methyl 4-hydroxybenzoate (3.0 g, 19.7 mmole)was reacted with 1-bromo-3-phenylpropane (3.1 mL, 20.4 mmole) to provide 4.8 g of methyl 4-(3-phenylpropyloxy)benzoate as a white crystalline solid, m.p. 61.0°-61.5° C.

Sources & evidence

ORD record
ord-0a866fabc97449baafa3fbe0338928ad
Source dataset
uspto-grants-1997_03
Patent number
US05612377

Reaction notes

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