p-Bromoacetophenone → 4-Bromo-1-(1,3-dithian-2-yl)ethylbenzene

HRID 976722Notes

Reaction equation

HRID 976722 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][CH:3]=1.[CH2:11]([SH:15])[CH2:12][CH2:13][SH:14].B(F)(F)F.[CH3:20]COCC>ClC(Cl)Cl.ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:9]2[S:15][CH2:11][CH2:12][CH2:13][S:14]2)[CH3:20])=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 7466p-BromoacetophenoneHCID 8000Boron trifluoride etherateHCID 80131,3-Propanedithiol

Product 1

HCID 219601124-Bromo-1-(1,3-dithian-2-yl)ethylbenzene

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent

Procedure

To the compound p-bromoacetophenone (36.85 g, 185 mmol) in trichloromethane (300 ml) was added 1,3-propanedithiol (25 g, 230 mmol) and boron trifluoride etherate (3 ml). The resulting mixture was stirred at room temperature for 48 hours. The mixture was diluted with dichloromethane (500 ml), washed twice with 10% sodium hydroxide (200 ml), water, and brine, and then dried (Na2SO4). The product was concentrated to an oil. A portion was stirred with ether (100 ml) and a crystalline product was formed. The crystalline product was recovered by filtration and purified by recrystallization to yield 4-bromo-1-(1,3-dithian-2-yl)ethylbenzene.

Workup

  1. washwashed twice with 10% sodium hydroxide (200 ml), water, and brine
  2. dry with materialdried (Na2SO4)
  3. concentrationThe product was concentrated to an oil
  4. stirringA portion was stirred with ether (100 ml)
  5. customa crystalline product was formed
  6. filtrationThe crystalline product was recovered by filtration
  7. custompurified by recrystallization

Sources & evidence

ORD record
ord-5bd6d414c50446db90aa6a8df0e29dd3
Source dataset
uspto-grants-1997_03
Patent number
US05612342

Reaction notes

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