Diethyl Ether → HCID 19967571, compound

HRID 976946Notes

Reaction equation

HRID 976946 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[C:5]([O:10]C)[N:4]=1.[CH3:12]COCC>>[NH2:9][C:7]1[NH:8][CH:3]([S:2][CH3:1])[N:4]([CH3:12])[C:5](=[O:10])[CH:6]=1

Participants

3

Reactant 2

HCID 3283Diethyl EtherHCID 41219816-Methoxy-2-(methylsulfanyl)pyrimidin-4-amine

Product 1

HCID 19967571HCID 19967571, compoundYield 60%

Procedure

The compound soluble in ether was 2-methylmercapto-4-amino-6-methoxypyrimidine. This compound was removed from the solid residue by repeated washings with ether and filtering out of the solid residue. The solid residue was then recrystallized from alcohol to give 43 as slender prisms (yield=60%, m.p. 255° C.).

Workup

  1. customThis compound was removed from the solid residue
  2. washwashings with ether
  3. filtrationfiltering out of the solid residue
  4. customThe solid residue was then recrystallized from alcohol

Sources & evidence

ORD record
ord-cec0871f8b22467e8d18aa638134161a
Source dataset
uspto-grants-1997_03
Patent number
US05612468

Reaction notes

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