6-amino-3-methyl-2-methylsulfanyl-5-nitrosopyrimidin-4-one → 5,6-Diamino-3-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one

HRID 976947Notes

Reaction equation

HRID 976947 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[N:12]=O>[NH4+]=S>[NH2:12][C:3]1[C:4](=[O:11])[N:5]([CH3:10])[C:6]([S:8][CH3:9])=[N:7][C:2]=1[NH2:1]

Participants

2

Reactant 1

HCID 43919196-amino-3-methyl-2-methylsulfanyl-5-nitrosopyrimidin-4-one

Product 1

HCID 1816055,6-Diamino-3-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one

Procedure

To 4.0 g (0.02 mole) of 6-amino-3-methyl-2-methylthio-5-nitroso-pyrimidine-4-one (44) was added 40 mL of 20% aqueous ammonium sulfide solution. The mixture was heated under reflux for 30 min. After cooling the precipitate was collected, washed with a little ethanol and dried in a desiccator to give 45 as 2.72 g (75% yield) of colorless crystals (m.p. 211°-212° C.).

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 min
  3. temperatureAfter cooling the precipitate
  4. customwas collected
  5. washwashed with a little ethanol
  6. customdried in a desiccator

Sources & evidence

ORD record
ord-04ca4354890e41f89c29f6bc0da8aba2
Source dataset
uspto-grants-1997_03
Patent number
US05612468

Reaction notes

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