6-amino-3-methyl-2-methylsulfanyl-5-nitrosopyrimidin-4-one → 5,6-Diamino-3-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one

Participants

Reaction Steps

To 4.0 g (0.02 mole) of 6-amino-3-methyl-2-methylthio-5-nitroso-pyrimidine-4-one (44) was added 40 mL of 20% aqueous ammonium sulfide solution. The mixture was heated under reflux for 30 min. After cooling the precipitate was collected, washed with a little ethanol and dried in a desiccator to give 45 as 2.72 g (75% yield) of colorless crystals (m.p. 211°-212° C.).

Provenance & Evidence