HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Benzyl 3-(4-t-butoxycarbonylmethoxybenzoyl)carbazate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Benzyl carbazate | HCID 79242 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 4-(2-methoxy-2-oxoethoxy)benzoic acid | HCID 13816142 | — |
| Product | Benzyl 3-(4-t-butoxycarbonylmethoxybenzoyl)carbazate | HCID 19610493 | — |
Reaction Steps
In a similar manner to Example 9, starting material step (a), 4-methoxycarbonylmethoxybenzoic acid (580 mg), HBTU (1.04 g), HOBT (420 mg), diisopropylethylamine (1.41 ml), DMF (7.5 ml) and benzyl carbazate (500 mg) were reacted to give benzyl 3-(4-t-butoxycarbonylmethoxybenzoyl)carbazate (550 mg) as an off-white solid; NMR Spectrum (DMSO-d6) 3.70 (3H, s), 4.88 (2H, s), 5.11 (2H, s), 7.03 (2H, d), 7.82 (2H, d), 7.38 (5H, m), 9.28 (1H, br s), 10.20 (1H, br s); Mass Spectrum m/z 359 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05612373 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-881a74f2d45943b3b958c125e2f841e9 |
| Source note | uspto-grants-1997_03 |