Phenol → HCID 14745383, compound

HRID 977043Notes

Reaction equation

HRID 977043 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:8][C:9]([Cl:16])([Cl:15])[C:10]([N:12]=[C:13]=[O:14])=[O:11]>O.CC(C)=O>[Cl:8][C:9]([Cl:16])([Cl:15])[C:10]([NH:12][C:13](=[O:14])[O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:11]

Participants

5

Reactant 2

HCID 996PhenolHCID 76400Trichloroacetyl isocyanate

Product 1

HCID 14745383HCID 14745383, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

4.7 g (0.05 mol) of phenol are dissolved in a mixture of 10 g of water and 10 g of acetone. 9.4 g (0.05 mol) of trichloroacetyl isocyanate are subsequently added dropwise over the course of 30 minutes. The mixture is stirred at room temperature for 30 minutes and under reflux for 2.5 hours. The solvent mixture is evaporated in a rotary evaporator, and the solid obtained is recrystallized from DMSO.

Workup

  1. temperatureunder reflux for 2.5 hours
  2. customThe solvent mixture is evaporated in a rotary evaporator
  3. customthe solid obtained
  4. customis recrystallized from DMSO

Sources & evidence

ORD record
ord-9983c0be205c45a1bdab269d782235cc
Source dataset
uspto-grants-1997_03
Patent number
US05614351

Reaction notes

Loading…