Hydrochloric Acid → HCID 53932705, compound

HRID 977062Notes

Reaction equation

HRID 977062 reaction equation
[OH-].[Na+].[CH3:3][O:4][N:5]=[C:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:7]([O:9]CC)=[O:8].Cl>CO>[CH3:3][O:4][N:5]=[C:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:7]([OH:9])=[O:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53698905HCID 53698905, compound

Product 1

HCID 53932705HCID 53932705, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An aqueous solution of 0.90 g (22.6 mmol) of sodium hydroxide was added to a solution in methanol of 0.47 g (2.3 mmol) of ethyl α-methoxyiminophenylacetate (the less polar isomer prepared above). The resulting mixture was stirred overnight at room temperature. The reaction mixture was poured into 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated to give the title compound as a crude product, which was used in the subsequent reaction without further purification.

Workup

  1. customprepared above)
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried over anhydrous magnesium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-92f76f2dddea4bde8c1d0494b71324c3
Source dataset
uspto-grants-1997_03
Patent number
US05614470

Reaction notes

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