Methanol → HCID 86750593, compound

HRID 977073Notes

Reaction equation

HRID 977073 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:15]([C:16]([OH:18])=[O:17])[CH:14]3[N:9]([CH2:10][CH2:11][C:12]4[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=43)[C:8](=[O:23])[C:7]=2[CH:24]=1.S(Cl)(Cl)=O.[CH3:29]O>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C@@H:15]([C:16]([O:18][CH3:29])=[O:17])[C@@H:14]3[N:9]([CH2:10][CH2:11][C:12]4[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=43)[C:8](=[O:23])[C:7]=2[CH:24]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 19964379HCID 19964379, compound

Product 1

HCID 86750593HCID 86750593, compound

Procedure

A suspension of 14 g (43.3 mmol ) of 10-methoxy-8-oxo-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine-13-carboxylic acid in 100 ml of methanol is prepared in a 500 ml three-necked round-bottomed flask, 3.2 ml (44.11 mmol) of thionyl chloride are added dropwise and the mixture is heated to reflux for 4 h.

Workup

  1. customis prepared in a 500 ml three-necked round-bottomed flask
  2. temperaturethe mixture is heated
  3. temperatureto reflux for 4 h.

Sources & evidence

ORD record
ord-087a6d32b33d472d96d40c1361e87486
Source dataset
uspto-grants-1997_03
Patent number
US05614517

Reaction notes

Loading…