HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate → 4-Methylthiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate | HCID 19965170 | — |
| Solvent | Diethylamine | HCID 8021 | — |
| Product | 4-Methylthiazole-5-carboxylic acid | HCID 209805 | 56% |
Reaction Steps
Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate in diethylamine was heated in the same manner as that of Example 35 and hydrolyzed to give 2-(4-N,N-diethylamino)-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid (yield: 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614520 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-485b47014fbb4749a2cbe6fe00189ca3 |
| Source note | uspto-grants-1997_03 |