Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate → 4-Methylthiazole-5-carboxylic acid

HRID 977099Notes

Reaction equation

HRID 977099 reaction equation
ClC1C=CC([C:8]2[S:9][C:10]([C:14]([O:16]CC)=[O:15])=[C:11]([CH3:13])[N:12]=2)=CC=1[N+]([O-])=O>C(NCC)C>[CH3:13][C:11]1[N:12]=[CH:8][S:9][C:10]=1[C:14]([OH:16])=[O:15]

Participants

3

Reactant 1

HCID 19965170Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

Product 1

HCID 2098054-Methylthiazole-5-carboxylic acidYield 56%

Reagents, catalysts & solvents 1

HCID 8021DiethylamineSolvent

Procedure

Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate in diethylamine was heated in the same manner as that of Example 35 and hydrolyzed to give 2-(4-N,N-diethylamino)-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid (yield: 56%).

Sources & evidence

ORD record
ord-485b47014fbb4749a2cbe6fe00189ca3
Source dataset
uspto-grants-1997_03
Patent number
US05614520

Reaction notes

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