HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 19965119, compound → HCID 19965137, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 19965119 | HCID 19965119 | — |
| Reactant | Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate | HCID 19965170 | — |
| Solvent | Piperidine | HCID 8082 | — |
| Product | HCID 19965137 | HCID 19965137 | 63% |
Reaction Steps
As described in Example 37, ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate was reacted in piperidine, and the resulting ethyl 4-methyl-2-(3-nitro-4-piperidinophenyl)-5-thiazolecarboxylate was hydrolyzed by a conventional process to give 135 mg of 4-methyl-2-(3-nitro-4-piperidinophenyl)-5-thiazolecarboxylic acid (yield: 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614520 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-148ad2d628a34c9da75136af8252d97d |
| Source note | uspto-grants-1997_03 |