HCID 19965119, compound → HCID 19965137, compound

HRID 977101Notes

Reaction equation

HRID 977101 reaction equation
ClC1C=CC(C2SC(C(OCC)=O)=C(C)N=2)=CC=1[N+]([O-])=O.[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]3)=[C:35]([N+:45]([O-:47])=[O:46])[CH:34]=2)[S:26][C:27]=1[C:28]([O:30]CC)=[O:29]>N1CCCCC1>[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]3)=[C:35]([N+:45]([O-:47])=[O:46])[CH:34]=2)[S:26][C:27]=1[C:28]([OH:30])=[O:29]

Participants

4

Reactant 2

HCID 19965119HCID 19965119, compoundHCID 19965170Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

Product 1

HCID 19965137HCID 19965137, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

As described in Example 37, ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate was reacted in piperidine, and the resulting ethyl 4-methyl-2-(3-nitro-4-piperidinophenyl)-5-thiazolecarboxylate was hydrolyzed by a conventional process to give 135 mg of 4-methyl-2-(3-nitro-4-piperidinophenyl)-5-thiazolecarboxylic acid (yield: 63%).

Sources & evidence

ORD record
ord-148ad2d628a34c9da75136af8252d97d
Source dataset
uspto-grants-1997_03
Patent number
US05614520

Reaction notes

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