反应详情

As described in Example 37, ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate was reacted in piperidine, and the resulting ethyl 4-methyl-2-(3-nitro-4-piperidinophenyl)-5-thiazolecarboxylate was hydrolyzed by a conventional process to give 135 mg of 4-methyl-2-(3-nitro-4-piperidinophenyl)-5-thiazolecarboxylic acid (yield: 63%).