HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylate → HCID 19965093, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylate | HCID 19965166 | — |
| Reactant | Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate | HCID 19965170 | — |
| Solvent | 1-Methylpiperazine | HCID 53167 | — |
| Product | HCID 19965093 | HCID 19965093 | 58% |
Reaction Steps
As described in Example 37, ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate was reacted in 1-methylpiperazine, and the resulting ethyl 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylate was hydrolyzed by a conventional process to give 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylic acid (yield: 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614520 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-b79b11818ac64e6fb4a8c87188d97185 |
| Source note | uspto-grants-1997_03 |