HCID 19965166, compound → HCID 19965093, compound

HRID 977103Notes

Reaction equation

HRID 977103 reaction equation
ClC1C=CC(C2SC(C(OCC)=O)=C(C)N=2)=CC=1[N+]([O-])=O.[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]3)=[C:35]([N+:46]([O-:48])=[O:47])[CH:34]=2)[S:26][C:27]=1[C:28]([O:30]CC)=[O:29]>CN1CCNCC1>[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]3)=[C:35]([N+:46]([O-:48])=[O:47])[CH:34]=2)[S:26][C:27]=1[C:28]([OH:30])=[O:29]

Participants

4

Reactant 2

HCID 19965166HCID 19965166, compoundHCID 19965170Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

Product 1

HCID 19965093HCID 19965093, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 531671-MethylpiperazineSolvent

Procedure

As described in Example 37, ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate was reacted in 1-methylpiperazine, and the resulting ethyl 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylate was hydrolyzed by a conventional process to give 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylic acid (yield: 58%).

Sources & evidence

ORD record
ord-b79b11818ac64e6fb4a8c87188d97185
Source dataset
uspto-grants-1997_03
Patent number
US05614520

Reaction notes

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