4-(2-bromoacetyl)benzoic Acid → HCID 67712514, compound

HRID 977156Notes

Reaction equation

HRID 977156 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[Br:10][CH2:11][C:12]([C:14]1[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=1)=O>C(O)C>[BrH:10].[C:8]([C:6]1[CH:5]=[CH:4][N:3]2[CH:11]=[C:12]([C:14]3[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=3)[N:1]=[C:2]2[CH:7]=1)#[N:9]

Participants

4

Reactant 2

HCID 27568364-(2-bromoacetyl)benzoic AcidHCID 70155242-Aminoisonicotinonitrile

Product 1

HCID 67712514HCID 67712514, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8.5 g of 2-amino-4-cyanopyridine and 27.5 g of 4-bromoacetylbenzoic acid are boiled in 260 ml of ethanol for 20 h. After cooling, the precipitate is filtered off with suction and subjected to the customary working-up. 4-(7-Cyanoimidazo[1,2-a]pyridin-2-yl)benzoic acid hydrobromide is obtained, m.p. >310°.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate is filtered off with suction

Sources & evidence

ORD record
ord-2d441bdfff8c4b6f80a64eb6948a9912
Source dataset
uspto-grants-1997_03
Patent number
US05614531

Reaction notes

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