HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178472114, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3,5-Dimethyl-1H-pyrazole-1-carboxamidine mononitrate | HCID 198186 | — |
| Reactant | HCID 54042044 | HCID 54042044 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178472114 | HCID 178472114 | 74.3% |
Reaction Steps
Ethyl β-[[[[7-aminoheptyl]amino]carbonyl]amino]-3-pyridinepropanoate (1.2 g; 3 mmoles), 3,5-dimethylpyrazole-1-carboxamidine nitrate (2.6 g; 13.3 mmoles) and diisopropylethylamine (3.74 g; 28.7 mmoles) were stirred in dioxane (25 ml) and water (10 ml) for 22 hrs. The mixture was taken down to dryness under reduced pressure and the residue was purified by HPLC using a linear gradient of 5-45% acetonitrile/water/trifluoroacetic acid. The desired fractions were collected and lyophilized to give 875 mg of clear oily material. FAB-MS: MH+ =393.2. Elemental analysis: C19H32N6O3 ·CF3COOH·4H2O
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614539 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-83a3a78901134b7b8dab5370f867ca56 |
| Source note | uspto-grants-1997_03 |