Piperidine → HCID 53887833, compound

HRID 977207Notes

Reaction equation

HRID 977207 reaction equation
[NH:1]1[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[OH:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([Cl:18])[C:16]=1[OH:17])[CH:12]=O.N1CCCCC1>C(O)(=O)C>[OH:8][C:9]1[CH:10]=[C:11]([CH:12]=[C:7]2[C:5](=[O:6])[NH:4][C:2](=[S:3])[NH:1]2)[CH:14]=[C:15]([Cl:18])[C:16]=1[OH:17]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 12740302-ThiohydantoinHCID 24681823-Chloro-4,5-dihydroxybenzaldehyde

Product 1

HCID 53887833HCID 53887833, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A solution containing 1.16 g of thiohydantoin, 1.72 g of 3,4-dihydroxy-5-chlorobenzaldehyde and 0.2 ml of piperidine in 20 ml of acetic acid was heated for 4 h at 100° C. The product was filtered and washed with ether. Yield 1.0 g, mp 303°-304° C.

Workup

  1. filtrationThe product was filtered
  2. washwashed with ether

Sources & evidence

ORD record
ord-002870a0ee3649d3afd35d29445e7291
Source dataset
uspto-grants-1997_03
Patent number
US05614541

Reaction notes

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