反应详情

1 g of 4-(2-oxo-5-hydroxymethyloxazolidin-3-yl)benzonitrile [obtainable according to EP 300 272] dissolved in 12 ml of acetonitrile is added at 16° to a solution of 3.6 g of Na dihydrogen phosphate dihydrate, 3.9 g of Na metaperiodate and 36 mg of RuCl3 in 23 ml of water/2.3 ml of dichloromethane. The reaction mixture is stirred at room temperature for 12 h, filtered and given the customary workup. Concentration by evaporation to dryness in vacuo gives 3-(4-cyanophenyl)-2-oxo-5-oxazolidinecarboxylic acid, m.p. 204°.

1. filtrationfiltered
2. concentrationConcentration
3. customby evaporation to dryness in vacuo