Ethyl Acetate → Tert-butyl 1-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl}piperid-4-yl-carboxylate

Participants

Reaction Steps

1.37 g of tert-butyl 1-{3-[4-(5-oxo-1,2,4-oxadiazolin-3-yl)phenyl]-2-oxo-5-oxazolidinylcarbonyl}piperidine-4-carboxylate are dissolved in 50 ml of methanol and hydrogenated over Raney nickel. The reaction mixture is, subsequently filtered and the filtrate is concentrated in vacuo. The product obtained is treated with 20 ml of ethyl acetate, with heating, and the product, after cooling, is filtered off with suction. Tert-butyl 1-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl}piperid-4-yl-carboxylate is obtained, m.p. 160°.

Provenance & Evidence