Methanol → HCID 136381084, compound

HRID 977226Notes

Reaction equation

HRID 977226 reaction equation
[O:1]=[C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH2:17][CH:16]([C:18]([NH:20][CH2:21][CH2:22][C:23]([O:25]C)=[O:24])=[O:19])[O:15][C:14]3=[O:27])=[CH:9][CH:8]=2)[NH:3]1.CO.C(=O)([O-])[O-].[K+].[K+]>O>[O:1]=[C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH2:17][CH:16]([C:18]([NH:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[O:19])[O:15][C:14]3=[O:27])=[CH:11][CH:12]=2)[NH:3]1

Participants

5

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 136153578HCID 136153578, compound

Product 1

HCID 136381084HCID 136381084, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.12 g of methyl 3-{3-[4-(5-oxo-1,2,4-oxadiazolin-3-yl)phenyl]-2-oxo-5-oxazolidinylcarbonylamino}propionate [obtainable according to Example 4] are stirred at room temperature for 3 h in 13.5 ml of water and 30 ml of methanol with the addition of 1.35 g of potassium carbonate. The reaction solution is then given the customary workup. 3-{3-[4-(5-Oxo-1,2,4-oxadiazolin-3-yl)phenyl]-2-oxo-5-oxazolidinylcarbonylamino)propionic acid is obtained, m.p. 221°-223°.

Sources & evidence

ORD record
ord-bea8f4a57a5047d890e75788f2ed7415
Source dataset
uspto-grants-1997_03
Patent number
US05614535

Reaction notes

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