反应详情

A solution of 0.6 g of 9-nitro-20(S)-camptothecin in 7.5 ml of DMF was hydrogenated at room temperature and atmospheric pressure in the presence of 0.02 g of 10% Pd/C for four hours. The catalyst was filtered off, and washed with warm DMF repeatedly. The solution was evaporated in vacuo and the crude reaction mixture was purified by column chromatography, to yield the title product.

1. customwas hydrogenated at room temperature
2. filtrationThe catalyst was filtered off
3. washwashed with warm DMF repeatedly
4. customThe solution was evaporated in vacuo
5. customthe crude reaction mixture
6. customwas purified by column chromatography