Tetrahydrofuran → Tert-butyl 5-chloro-2-{3,3-difluoro-2-[(4-methoxyphenyl)amino]propyl}benzylcarbamate

HRID 97771Notes

Reaction equation

HRID 97771 reaction equation
[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH:1]([Li:2])([CH2:3][CH3:4])[CH3:5].[Cl:6][c:7]1[cH:8][cH:9][c:10]([CH3:22])[c:11]([CH2:12][NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[cH:21]1.[F:23][CH:24]([CH:25]=[N:26][c:27]1[cH:28][cH:29][c:30]([O:33][CH3:34])[cH:31][cH:32]1)[F:35]>>[Cl:6][c:7]1[cH:8][cH:9][c:10]([CH2:22][CH:25]([CH:24]([F:23])[F:35])[NH:26][c:27]2[cH:28][cH:29][c:30]([O:33][CH3:34])[cH:31][cH:32]2)[c:11]([CH2:12][NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[cH:21]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 10397509N-(2,2-difluoroethylidene)-4-methoxyanilineHCID 18672379Tert-butyl 5-chloro-2-methylbenzylcarbamateHCID 178418400CID 53628100

Product 1

HCID 18672390Tert-butyl 5-chloro-2-{3,3-difluoro-2-[(4-methoxyphenyl)amino]propyl}benzylcarbamate

Sources & evidence

ORD record
ord-16b97f64b2334ee8a3ddcc530eea18db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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