Ethylene Glycol → HCID 19966073, compound

HRID 977878Notes

Reaction equation

HRID 977878 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10]Cl)[C:5]=1[NH:12][C:13](=[O:29])[CH2:14][CH:15]1[C:28]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:22][C:21]2[C:16]1=[CH:17][CH:18]=[CH:19][CH:20]=2)([CH3:3])[CH3:2].[CH2:30]([OH:33])[CH2:31][OH:32]>>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:32][CH2:31][CH2:30][OH:33])[C:5]=1[NH:12][C:13](=[O:29])[CH2:14][CH:15]1[C:28]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:22][C:21]2[C:16]1=[CH:17][CH:18]=[CH:19][CH:20]=2)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 174Ethylene GlycolHCID 19966136HCID 19966136, compound

Product 1

HCID 19966073HCID 19966073, compoundYield 52%

Procedure

Following a procedure similar to that described in Preparation 1(ii), but using N-(2-isopropyl-6-chloromethylphenyl)-2-(9H-xanthen-9-yl)acetamide [prepared as described in Preparation 28(iv)] and ethylene glycol as starting materials, in relative amounts similar to those used in that Preparation, the title compound, melting at 153°-154° C. (after recrystallization from a mixture of diethyl ether and hexane), was obtained in a 52% yield.

Workup

  1. customin relative amounts similar to those used in that Preparation
  2. customthe title compound, melting at 153°-154° C. (after recrystallization
  3. additionfrom a mixture of diethyl ether and hexane),
  4. customwas obtained in a 52% yield

Sources & evidence

ORD record
ord-e5ba70adab924f1c9b24e1aa7507b564
Source dataset
uspto-grants-1997_03
Patent number
US05614550

Reaction notes

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