1-(Phenylmethyl) 4-carboxybenzeneacetate → N-[2-t-Butyl-5-[3-(4-benzyloxycarbonylmethylbenzoyloxy)-4-cyclohexylbutyl]phenyl}-2-(9H-xanthen-9-yl)acetamide

HRID 977889Notes

Reaction equation

HRID 977889 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[CH:6][CH:5]=1)([OH:3])=[O:2].[C:21]([C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][CH:33](O)[CH2:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)=[CH:27][C:26]=1[NH:42][C:43](=[O:59])[CH2:44][CH:45]1[C:58]2[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=2[O:52][C:51]2[C:46]1=[CH:47][CH:48]=[CH:49][CH:50]=2)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][CH:33]([O:2][C:1](=[O:3])[C:4]2[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[O:12])=[CH:8][CH:9]=2)[CH2:34][CH:35]2[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]2)=[CH:27][C:26]=1[NH:42][C:43](=[O:59])[CH2:44][CH:45]1[C:58]2[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=2[O:52][C:51]2[C:46]1=[CH:47][CH:48]=[CH:49][CH:50]=2)([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 199660801-(Phenylmethyl) 4-carboxybenzeneacetateHCID 19966195HCID 19966195, compound

Product 1

HCID 19966156N-[2-t-Butyl-5-[3-(4-benzyloxycarbonylmethylbenzoyloxy)-4-cyclohexylbutyl]phenyl}-2-(9H-xanthen-9-yl)acetamide

Procedure

Following a procedure similar to that described in Preparation 25, but using benzyl 4-carboxyphenylacetate [prepared as described in step (iv) above] and N-[2-t-butyl-5-(4-cyclohexyl-3-hydroxybutyl)phenyl]-2-(9H-xanthen-9-yl)acetamide (prepared as described in Example 12) as starting materials, in relative proportions similar to those used in that Preparation, the title compound was obtained as a foam-like material.

Workup

  1. customthat described in Preparation 25
  2. customin relative proportions similar to those used in that Preparation

Sources & evidence

ORD record
ord-27cf3ecbe07b4b4992680acbdba80d7c
Source dataset
uspto-grants-1997_03
Patent number
US05614550

Reaction notes

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