2-(1-Phenylcyclopentyl)acetic acid → N-{2-t-Butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]phenyl}-2-(1-phenylcyclopentyl)acetamide

HRID 977891Notes

Reaction equation

HRID 977891 reaction equation
[C:1]1([C:7]2([CH2:12][C:13]([OH:15])=O)[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]([C:20]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][CH:29]([O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])[CH2:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)=[CH:23][C:21]=1[NH2:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([C:20]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][CH:29]([O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])[CH2:30][CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]2)=[CH:23][C:21]=1[NH:22][C:13](=[O:15])[CH2:12][C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][CH2:9][CH2:10][CH2:11]1)([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 199660452-(1-Phenylcyclopentyl)acetic acidHCID 199662172-t-Butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]aniline

Product 1

HCID 19966114N-{2-t-Butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]phenyl}-2-(1-phenylcyclopentyl)acetamide

Procedure

Following a procedure similar to that described in Example 21, but using 2-(1-phenylcyclopentyl)acetic acid [prepared as described in Preparation 21] and 2-t-butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]aniline [prepared by a procedure similar to that described in Preparation 11(i)] as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a foam-like material.

Workup

  1. customprepared by a procedure similar to

Sources & evidence

ORD record
ord-51c15e470b5349ea82df656f51c82323
Source dataset
uspto-grants-1997_03
Patent number
US05614550

Reaction notes

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