反应详情

The 2-[4-(3,5-dichloropyridin-2-yloxy)phenoxy]propanoic acid chloride (3.12 grams; 0.009 mol); triethylamine (5 ml): 2,4-dichlorophenoxyethethanol (1.94 grams; 0.0094 mol) and toluene (100 ml) were stirred in a glass reaction flask until thin layer chromatographic analysis showed completion of the reaction. This mixture was transferred to a separatory funnel and washed three times with water (70 ml). The washed material was dried and stripped to a yellow/brown gum (4.8 grams) that solidified on standing and was recrystallized from a mixture of methylene chloride and hexane. The first crop (1.5 grams) analyzed by elemental analysis as follows:

1. customcompletion of the reaction
2. customThis mixture was transferred to a separatory funnel
3. washwashed three times with water (70 ml)
4. customThe washed material was dried
5. customwas recrystallized from a mixture of methylene chloride and hexane