反应详情

Heat 126 gm of the aldehyde of Step C in a mixture of 1500 cc of glacial acetic acid and 1500 cc of 48% hydrogen bromide in an oil bath at 150° C. with mechanical stirring until no trace of non-demethylated product remains (4-5 days). Cool the reaction mixture and pour into 7 l. of water. Separate the precipitate, wash well with water and dry in vacuo at 70° C. to constant weight. The material is used in the following step without further purification.

1. custom(4-5 days)
2. temperatureCool the reaction mixture
3. additionpour into 7 l
4. customSeparate the precipitate
5. washwash well with water
6. customdry in vacuo at 70° C. to constant weight
7. customThe material is used in the following step without further purification