HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(o-Carboxyphenylthio)-4-hydroxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Formate | HCID 2723810 | — |
| Reactant | 3-(o-Carboxyphenylthio)-4-hydroxybenzaldehyde | HCID 13338686 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 3-(o-Carboxyphenylthio)-4-hydroxybenzonitrile | HCID 13338687 | — |
Reaction Steps
Reflux 91.3 gm of the aldehyde of Step D, 27.4 gm of hydroxylamine hydrochloride and 41.9 gm of sodium formate in 900 cc of formic acid (98-100%) for 11/4 hours. Cool the mixture and pour into 21/2 l. of cold water. Separate the precipitate, wash with water and dry in vacuo at 75° C. The material is sufficiently pure for utilization in the subsequent step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04663307 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-b8d0728ddf864306a38aee09e6ca552f |
| Source note | uspto-grants-1987_05 |