反应详情

Reflux 91.3 gm of the aldehyde of Step D, 27.4 gm of hydroxylamine hydrochloride and 41.9 gm of sodium formate in 900 cc of formic acid (98-100%) for 11/4 hours. Cool the mixture and pour into 21/2 l. of cold water. Separate the precipitate, wash with water and dry in vacuo at 75° C. The material is sufficiently pure for utilization in the subsequent step.

1. temperatureCool the mixture
2. additionpour into 21/2 l
3. customSeparate the precipitate
4. washwash with water
5. customdry in vacuo at 75° C