Triethylamine → 5-(4-chlorobenzylthio)-4-chloro-2-phenylpyridazin-3(2H)-one

HRID 977929Notes

Reaction equation

HRID 977929 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][SH:7])=[CH:4][CH:3]=1.[Cl:10][C:11]1[C:12](=[O:24])[N:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:14]=[CH:15][C:16]=1Cl.C(N(CC)CC)C>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:7][C:16]2[CH:15]=[N:14][N:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:12](=[O:24])[C:11]=2[Cl:10])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 728134,5-Dichloro-2-phenyl-3(2H)-pyridazinoneHCID 804094-Chlorobenzyl mercaptan

Product 1

HCID 92819305-(4-chlorobenzylthio)-4-chloro-2-phenylpyridazin-3(2H)-oneYield 84%

Procedure

The reaction of 15.8 g (100 millimoles) of 4-chlorobenzyl mercaptan with 24.1 g (100 millimoles) of 4,5-dichloro-2-phenylpyridazin-3(2H)-one and 10.1 g (100 millimoles) of triethylamine is carried out as described in Method 2 and gives 30.5 g (84%) of a material which is found to be pure by thin-layer chromatography and has a melting point of 154°-155° C.

Sources & evidence

ORD record
ord-87683afd67ce452daa88d00961da9668
Source dataset
uspto-grants-1987_05
Patent number
US04663324

Reaction notes

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