反应详情

One-hundred and twelve grams concentrated sulfuric acid is added to 42 ml 90% nitric acid at 70°-80° C. To this 39 grams 1,3-dimethylpyrazole-5-carboxylic acid is added in portions over one hour such that temperature does not go over 90° C. After 2.5 hours the reaction mixture was cooled and poured over ice. The resulting percipitate was filtered, dried, and recrystallized in ethanol, to produce 1,3-dimethyl-4-nitropyrazol-5-carboxylic acid having mp 141°-142° C.

1. customdoes not go over 90° C
2. temperatureAfter 2.5 hours the reaction mixture was cooled
3. additionpoured over ice
4. filtrationThe resulting percipitate was filtered
5. customdried
6. customrecrystallized in ethanol