Hydrochloric Acid → 2,4-Piperidinedione, 1-(2-phenylethyl)-

HRID 977944Notes

Reaction equation

HRID 977944 reaction equation
[CH2:1]([N:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH:11](C(=O)C)[C:10]1=[O:19])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl>C(O)C>[CH2:1]([N:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][C:10]1=[O:19])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20204026HCID 20204026, compound

Product 1

HCID 106088042,4-Piperidinedione, 1-(2-phenylethyl)-Yield 86.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Phenethyl-3-acetyl-2,4-dioxopiperidine (5.0 g) and 10% hydrochloric acid (30 ml) are added to ethanol (50 ml), and the mixture is refluxed for 6 hours. After distilling off the solvent, the residue is dissolved in chloroform, and the solution is washed with a saturated sodium chloride solution, dried and then distilled to remove the solvent to give 1-phenethyl-2,4-dioxopiperidine (3.62 g, 86.4%) as an oily substance.

Workup

  1. temperaturethe mixture is refluxed for 6 hours
  2. distillationAfter distilling off the solvent
  3. dissolutionthe residue is dissolved in chloroform
  4. washthe solution is washed with a saturated sodium chloride solution
  5. customdried
  6. distillationdistilled
  7. customto remove the solvent

Sources & evidence

ORD record
ord-0e59e46561b745debb684ac6e2cd1a5a
Source dataset
uspto-grants-1987_05
Patent number
US04663319

Reaction notes

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